人物经历
1983-1987：北京大学化学系，学士
1987-1990：北京大学化学系有机化学专业，硕士
1990-1993：北京大学化学系有机化学专业，博士
1993-1996：中国科学院上海有机化学研究所，博士后
1996-1998：以色列Weizmann科学研究所有机化学系，博士后
1999-2006：美国Wisconsin大学生物化学系和比较生物科学系，研究学者
2006-2008：美国Amherst College化学系，研究学者
2008-2017年在上海大学环境与化学工程学院环境污染与健康研究所任研究员，
2017年至今任上海交通大学医学院公共卫生学院研究员。[2]
社会任职
张新宇是多个专业协会会员，包括美国化学会、中国毒理学会、中国环境科学学会（高级会员）和中国药理学会（药物代谢专业委员会委员），并任Toxicology and Applied Pharmacology杂志编委。[2]
主要成就
研究方向1． 丁二烯毒性的分子机理研究
丁二烯是一个重要的石油化工产品，用于合成塑料和橡胶。但它也存在于汽车尾气、香烟烟雾、垃圾焚烧产生的烟雾中。因此，城市的空气中存在着低浓度的丁二烯。丁二烯是一个致癌物，被美国环境保护署列为187个“Air Toxic”之一。它的毒性源于其代谢产物，主要有2-乙烯基环氧乙烷、双环氧丁烷、3-丁烯-1,2-二醇和3,4-环氧-1,2-丁二醇。这些代谢产物能够与DNA和蛋白质反应产生各种加成产物。我们将重点研究这些代谢产物与蛋白质的相互作用，以及这种相互作用是怎样扰动细胞内的信号传导过程的。
2． 持久性有机污染物（persistent organic pollutants，POPs）毒性的分子机理研究
持久性有机污染物是一类有机化合物的统称。它们难于通过化学、生物和光解过程降解，因而在环境内长期存在和积累，并能通过食物链在生物组织中富集，进而对人的健康产生危害。POPs包括农药和杀虫剂（如滴滴涕和氯丹）、工业产品（主要指多氯联苯）和工业污染物（主要是二恶英）。这些污染物一般被认为是通过与细胞上的受体结合，扰乱细胞内的生理过程而起作用的。我们将用各种生物化学、分子生物学和细胞生物学的手段（特别是荧光技术）研究POPs对细胞内的信号传导过程的影响的分子机理。
学术成就主要从事化合物代谢、遗传毒性、DNA加合物和致癌机理的研究，研究领域涉及化学、毒理学、生物化学、细胞生物学以及环境科学。主持国家自然科学基金项目3项，在毒理学、分析化学和环境科学等学科国际知名期刊如Chemical Research in Toxicology、Analytical Chemistry和Environment International等发表论文20余篇，受邀撰写《Advances in Molecular Toxicology》（Vol. 12，Elsevier出版集团）中的一章。2017年获上海市自然科学奖三等奖。[2]
学术论文1. Zhang, X.-Y.; Bishop, A. C. Engineered Inhibitor Sensitivity in the Activation Loop of a Protein Tyrosine Phosphatase. Biochemistry 2008, 47, 4491.
2. Zhang, X.-Y.; Bishop, A. C. Site-Specific Incorporation of Allosteric-Inhibition Sites in a Protein Tyrosine Phosphatase. J. Am. Chem. Soc. 2007, 129, 3812-3813.
3. Bishop, A. C.; Zhang, X.-Y.; Lone, A. M. Generation of Inhibitor-Sensitive Protein Tyrosine Phosphatases via Active-Site Mutations. Methods 2007, 42, 278-288.
4. Zhang, X.-Y.; Elfarra, A. A. Characterization of 1,2,3,4-Diepoxybutane–2¢-Deoxyguanosine Cross-Linking Products Formed at Physiological and Non-Physiological Conditions. Chem. Res. Toxicol. 2006, 19, 547-555.
5. Zhang, X.-Y.; Elfarra, A. A. Reaction of 1,2,3,4-Diepoxybutane with 2¢-Deoxyguanosine: Initial Products and Their Stabilities and Decomposition Patterns under Physiological Conditions. Chem. Res. Toxicol. 2005, 18, 1316-1323.
6. Zhang, X.-Y.; Elfarra, A. A. Characterization of the Reaction Products of 2¢-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts. Chem. Res. Toxicol. 2004, 17, 521-528.
7. Zhang, X.-Y.; Elfarra, A. A. Identification and Characterization of a Series of Nucleoside Adducts Formed by the Reaction of 2¢-Deoxyguanosine and 1,2,3,4-Diepoxybutane under Physiological Conditions. Chem. Res. Toxicol. 2003, 16, 1606-1615.[1]
8.Wen-Jing Wu, Wei-Feng Tang, Ming-Hui Xiang*, Jianshe Yan, Xiumei Cao, Chang-Hui Zhou, Yan Chang, Jing Xi, Yi-Yi Cao, Yang Luan,Xin-Yu Zhang*, Isotope dilution LC/ESI-MS-MS quantitation of urinary 1,4-bis(N-acetyl-S-cysteinyl)-2-butanone in mice and rats as the biomarker of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene.Chemico-Biological Interactions2019,311, 108760.
9.Hao Xu, Chao Feng, Yiyi Cao, Ying Lu, Jing Xi, Jieyun Ji, Dasheng Lu*,Xin-Yu Zhang*, Yang Luan, Distribution of the parent compound and its metabolites in serum, urine, and feces of mice administered 2,2¢,4,4¢-tetrabromodiphenyl ether.Chemosphere2019,225, 217-225.
10.Xin-Yu Zhang*, Adnan A Elfarra*,Myeloperoxidase-mediated bioactivation of olefins.InAdvances in Molecular Toxicology,Vol. 12(J. C. Fishbein and J. M. Heilman Eds.) Chapter 4, Academic Press, Cambridge, USA,2018.
11.Xin-Yu Zhang, Adnan A Elfarra*,Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design.Expert Opinion on Drug Discovery2018,13, 815-824.https://www.tandfonline.com/eprint/vpsPKjTX8GDRNSBsvgch/full.
12.Ye Wang, Ying-Xin Yu, Yang Luan, Jing An, Dong-Guang Yin,Xin-Yu Zhang*, Bioactivation of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene, by rat liver microsomes.Chemico-Biological Interactions2018,282, 36-44.http://authors.elsevier.com/sd/article/S0009279717310918.
13.Xin-Yu Zhang*, Adnan A. Elfarra*, Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties.Expert Opinion on Drug Metabolism & Toxicology2017,13, 513-524.http://www.tandfonline.com/eprint/xIZWGQjBGdWgGKMVCkG2/full.
14.Ling-Yan Liu, Jin Zheng, Cong Kong, Jing An, Ying-Xin Yu,Xin-Yu Zhang*, Adnan A. Elfarra*, Characterization of the major purine and pyrimidine adducts formed after incubations of 1-chloro-3-buten-2-one with single-/double-stranded DNA and human cells.Chemical Research in Toxicology2017,30, 552-563.
15.Fang-Mao Zeng, Ling-Yan Liu, Jin Zheng, Cong Kong, Jing An, Ying-Xin Yu,Xin-Yu Zhang*, Adnan A. Elfarra*, Identification of a fused-ring 2¢-deoxyadenosine adduct formed in human cells incubated with 1-chloro-3-buten-2-one, a potential reactive metabolite of 1,3-butadiene.Chemical Research in Toxicology2016,29, 1041-1050.
16.Jin Zheng, Yan Li, Ying-Xin Yu, Jing An,Xin-Yu Zhang*, Adnan A. Elfarra*, Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2¢-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity.Chemico-Biological Interactions2015,226, 40-48.
17.Ying Wen, Keyin Liu, Huiran Yang, Yi Li, Haichuang Lan,Xinyu Zhang*, Tao Yi*, A highly sensitive ratiometric fluorescent probe for the detection of cytoplasmic and nuclear hydrogen peroxide.Analytical Chemistry2014,86, 9970-9976.
18.Liang Sun, Avishay Pelah, Dong-Ping Zhang, Yu-Fang Zhong, Jing An, Ying-Xin Yu,Xin-Yu Zhang*, Adnan A. Elfarra*, Formation of fused-ring 2¢-deoxycytidine adducts from 1-chloro-3-buten-2-one, an in vitro 1,3-butadiene metabolite, under in vitro physiological conditions.Chemical Research in Toxicology2013,26, 1545-1553.
19.Xin-Jie Liu, Fang-Mao Zeng, Jing An, Ying-Xin Yu,Xin-Yu Zhang*, Adnan A. Elfarra*, Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene.Toxicology and Applied Pharmacology2013,271, 13-19.
20.Pan-Pan Zhang, Ying Wen, Jing An, Ying-Xin Yu*, Ming-Hong Wu,Xin-Yu Zhang*, DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells.Mutation Research2012,747, 240-245.
21.Ying-Xin Yu, Yu-Ping Pang, Chen Li, Jun-Ling Li,Xin-Yu Zhang*, Zhi-Qiang Yu, Jia-Liang Feng, Ming-Hong Wu, Guo-Ying Sheng, Jia-Mo Fu, Concentrations and seasonal variations of polybrominated diphenyl ethers (PBDEs) in in- and out-house dust and human daily intake via dust ingestion corrected with bioaccessibility of PBDEs.Environment International2012,42, 124-131.
22.Ying Wen, Pan-Pan Zhang, Jing An, Ying-Xin Yu, Ming-Hong Wu, Guo-Ying Sheng, Jia-Mo Fu,Xin-Yu Zhang*, Diepoxybutane induces the formation of DNA-DNA rather than DNA-protein cross-links, and single-strand breaks and alkali-labile sites in human hepatocyte L02 cells.Mutation Research2011,716, 84-91.[2]
科研项目参加美国NIH课题2项，国家自然基金重点项目1项。[1]
