张全启（中国海洋大学教授）

学习与工作经历

1979-1983：中国海洋大学（原山东海洋学院）海洋生命学院，获理学学士学位。

1983-1986：中国海洋大学海洋生命学院，获理学硕士学位。

1986-1994：中国海洋大学海洋生命学院，助教、讲师。

1994.10-1998.2：日本广岛大学生物生产学部，获哲学博士学位。

1998.3-1999.2：美国威廉马丽大学海洋研究所，博士后。

1999.3-2001.2：日本水产养殖研究所科技厅特别研究员（博士后）。

1999.12—现在：中国海洋大学海洋生命学院教授、博士生导师。其中，

2003.10-2011.7期间，任中国海洋大学海洋生命学院院长。

主要研究领域

一直从事海洋生物遗传学和基因组学研究，主要研究内容包括：

（1）鱼类分子和遗传学及优良品种选育；

（2）鱼类染色体组操作与性别决定机制；

（3）鱼类基因组学和功能基因研究；

（4）鱼类胚胎干细胞、生殖干细胞分离培养、移植记借腹生子研究。

主要研究课题

1. 鲆鲽类高产、抗逆品种选育，国家“十一五”“863”课题，185万。2006-2010。副主持。

2.名贵海水鱼类苗种繁育，国家“十一五”“863”课题，60万。2006-2010。参加。

3.利用种间杂交构建牙鲆和石鲽遗传连锁图谱，国家自然科学基金，28万，2007-2009。主持。

4. 优质抗病速生鱼类良种选育，山东省农业良种工程重大课题，360万，2006-连续支持。首席。

5. 鲆鲽鱼类原始生殖细胞和精原细胞识别的分子基础及其分离鉴定，国家自然科学基金，58万，2010-2014。主持。

6. 泰山学者团队建设经费，山东省委组织部人才建设项目，25万，2010-2015。

7. 海洋动物细胞分子育种关键技术，国家“十二五”“863”课题，320万。2012-2015。主持。

8. 重要鲆鲽鱼类良种培育，国家“十二五”“863”课题，115万。2012-2015。子课题。

主要代表作

1. Dongyi Yu, Quanqi Zhang*, Zhigang Wang, Jie Qi, Xinglian Wang. 2008. Characterization on the alternative splicing, expression and gene phylogenesis of PTPR4 family in Japanese flounder,Paralichthys olivaceus. Genes and Genetic Systems 83(2), 189-197.

2. Qiwang Zhong, Quanqi Zhang*, Yanjie Chena, Yeying Suna, Jie Qia, Zhigang Wanga, Shuo Lia, Chunmei Liaand Xun Lan. 2008. The isolation and characterization of myostatin gene in Japanese flounder (Paralichthys olivaceus): Ubiquitous tissue expression and developmental specific regulation. Aquaculture, 281 (1-4): 247-255.

3. Qiwang Zhong, Quanqi Zhang*, Zhigang Wang, Jie Qi, Yanjie Chen, Shuo Li, Yeying Sun, Chunmei Li, Xun Lan, 2008. Expression Profiling and Validation of Potential Reference Genes DuringParalichthys olivaceusEmbryogenesis. Marine Biotechnology. 10(3): 310-318.

4. Xubo Wang, Quanqi Zhang*, Xiaohua Sun, Guoliang Yin, Jie Qi, Zhigang Wang And Xinglian Wang. 2008. Isolation and characterization of 64 novel microsatellite markers from a fosmid library of female half-smooth tongue sole (Cynoglossus semilaevis). Molecular Ecological Resources 2008(8): 1303-1306.

5. Xu xiaofei1, Zhang Quanqi*, Wang Zhigang，Qi Jie, Zhang Zhifeng, Bao Zhenming and Heisuke Nakagawa, 2006. Assessing genetic diversity of wild populations of Japanese flounder using AFLP markers, Acta Oceanologica Sinica.25(3): 82-89.

6. Xubo Wang, Quanqi Zhang*, Xiaohua Sun, Yanjie Chen, Teng Zhai, Wei Zhuang, Jie Qi and Zhigang Wang. 2009. Fosmid Library Construction and Initial Analysis of End Sequences in Female Half-smooth Tongue Sole (Cynoglossus semilaevis) Marine Biotechnology,

11(2): 236-

7.Yan Yu, Qiwang Zhong, Chunmei Li, Liming Jiang; Fusheng Yan; Zhigang Wang; Quanqi Zhang*, 2009. Isolation and characterization of Toll-like receptor 9 in half-smooth tongue sole Cynoglossus semilaevis. Fish and Shellfish Immunology. 26：492-499.

8.ZHANG Quanqi*, SUN Xiaohua, QI Jie, WANG Zhigang, WANG Xinglian, WANG Xubo, and ZHAI Teng. 2009. Sex Determination Mechanisms in Fish. J. Ocean Univ. China，8 (2): 155-160.

9. Chen Yanjie, Zhang Quanqi*, Qi Jie, Sun Yeying, Zhong Qiwang, Wang Xubo, Wang Zhigang, Li Shuo, Li Chunmei. 2009. Screening of eye-position related genes with DD-RT and RDA in the hybrids between Japanese flounder (Paralichthys olivaceus) and stone flounder (Kareius bicoloratus). Chinese Journal of Oceanology and Limmnology, 27(1): 92-99. (SCI)

10. Jianpeng Xu, Quanqi Zhang*, Xiaofei Xu, Zhigang Wang, Jie Qi. 2009. Intragenomic Variability and Pseudogenes of Ribosomal DNA in Stone Flounder Kareius bicoloratus. Molecular Phylogenetics and Evolution 52 (2009) 157-166.

11. Yan Yu, Qiwang Zhong, Chunmei Li, Liming Jiang; Fusheng Yan; Zhigang Wang; Quanqi Zhang*, 2009. Full-length sequence and expression analysis of a myeloid differentiation factor 88 (MyD88) in half-smooth tongue soleCynoglossus semilaevis. International Journal of Immunogenetics. 36: 173–182.

12. Qiwang Zhong, Yan Yu, Quanqi Zhang*, Zhigang Wang, Haiyang Yu. 2009. Isolation and characterization of twenty novel microsatellite markers for half-smooth tongue sole (Cynoglossus semilaevis), Conservation Genetics. 10: 1617–1620.

13. Xubo Wang, Quanqi Zhang*, Jian Ren, Zhanjun Jiang, Changmeng Wang, Wei Zhuang, Teng Zhai, 2009. The preparation of sex-chromosome-specific painting probes and construction of sex chromosome DNA library in half-smooth tongue sole (Cynoglossussemilaevis). Aquaculture, 297: 78-84. AQUA-

14. WANG Xubo, ZHANG Quanqi*, CHEN Yanjie, QI Jie, WANG Zhigang, WANG Xinglian, 2009. Cytogenetic characterization of olive flounderParalichthys olivaceus: DNA content, karyotype, AgNORs and location of major ribosomal genes. Acta Oceanologica Sinica, 28(4): 72-77.

15. Yeying Sun, Haiyang Yu, Quanqi Zhang*, Jie Qi, Qiwang Zhong, Yanjie Chen, Chunmei Li. 2010. Molecular characterization and expression pattern of two zona pellucida genes in half-smooth tongue sole (Cynoglossus semilaevis). Comparative Biochemistry and Physiology, Part B. 155 (2010) 316–321.

16. Shuo Li, Chunmei Li, Xubo Wang, Yanan Wang, Zhipeng Liu, Teng Zhai and Quanqi Zhang*. 2010. Molecular cloning and expression of PoIR2, a novel gene involved in immune response in Japanese flounder (Paralichthys olivaceus). Journal of Ocean University of China (English Edition), 9(1): 59-64.

17. Yeying Sun, Quanqi Zhang*, Jie Qi, Yanjie Chen, Qiwang Zhong, Yan Yu, Shuo Li, Zhigang Wang, Chunmei Li. 2010. Identification of differential genes in the ovary relative to the testis and their expression patterns in half-smooth tongue sole (Cynoglossus semilaevis). J. Genet. Genomomics, 37 (2): 137-145.

18. CHEN Yanjie, ZHANG Quanqi*, QI Jie, WANG Zhigang, WANG Xubo, SUN Yeying, ZHONG Qiwang, LI Shuo, LI Chunmei. 2010. Cloning and stage-specific expression of CK-M1 gene during metamorphosis of Japanese flounder,Paralichthys olivaceus. Chinese Journal of Oceanology and Limmnology, 28(3): 558-564.

19.Yuding Fan, Shuo Li, Jie Qi, Lingbing Zeng, Qiwang Zhong, Quanqi Zhang*. 2010. Cloning and characterization of type II Interleukin-1 receptor cDNA from Japanese flounder (Paralichthys olivaceus). Comparative Biochemistry and Physiology, Part B. 157: 59–65.

20. Jiashi Wang, Haiyang Yu, Hui Huang, Zhongjia Huang, Xubo Wang, Zhigang Wang & Quanqi Zhang*. 2009. Isolation and characterization of 21 novel microsatellite markers from spotted halibut (Verasper variegatus). Aquaculture Research，2010, 41, 930-933.

21.Quanqi Zhang*, Haiyang Yu, Aimee Howe, Whitney Chandler & Standish K. Allen Jr. 2010. Cytogenetic mechanism for reversion of triploids to heteroploid mosaics inCrassostrea gigas (Thunberg) andCrassostrea ariakensis. Aquaculture Research, 41, 1658-1667.

22. Quanqi Zhang*, Yan Zhuang and Standish K. Allen. 2010. Meiotic chromosome configurations in triploid and heteroploid mosaic males ofCrassostrea gigas andCrassostrea. ariakensis. Aquaculture Research, 41, 1699-1706.

23. Li, C., Yu, Y., Sun, Y., Li, S., Zhong, Q., Wang, X., Wang, Z., Qi, J., Zhang, Q*. 2010. Isolation, polymorphism and expression study of two distinct major histocompatibility complex class II B genes from half-smooth tongue sole (Cynoglossus semilaevis). Intern. J. Immunogenet. 37(3):185-197.

24.Zhang J. Y., Wang W. J., Meng X. H., Kong J., Wang Q. Y., and Zhang Q. Q*. 2011. Genotyping of Single Nucleotide Polymorphisms inFenneropenaeus chinensis (Decapoda, Penaeidae) by Tetra-Primer ARMA-PCR. Russian Journal of Marine Biology. 401-408.

25. Chunmei Li, Quanqi Zhang*, Yan Yu, Shuo Li, Qiwang Zhong, Yeying Sun, Zhigang Wang, Jie Qi, Jieming Zhaiand Xubo Wang. 2011. Sequence polymorphism of two major histocompatibility (MH) class II B genes and their association with Vibrio anguillarum infection in half-smooth tongue sole (Cynoglossus semilaevis). Chinese Journal of Oceanology and Limnology, 29 (6): 1275-1286.

26. LI Chunmei, WANG Xubo, ZHANG Quanqi*, WANG Zhigang, QI Jie, YI Qilin, LIU Zhipeng, WANG Yanan, and YU Haiyang. 2012. Identification of two Major Histocompatibility (MH) Class IIA Genes and Their Association toVibrio anguillarum Infection in Half-smooth Tongue Sole (Cynoglossus semilaevis). J. Ocean Univ. China 2011 10 (4): 106-112.

27. Yan Yu, Qiwang Zhong, Chunmei Li, Liming Jiang, Yanan Wang, Yeying Sun, Xubo Wang, Zhigang Wang, Quanqi Zhang*. 2012. Identification and characterization of IL-1 receptor-associated kinase-4 (IRAK-4) in half-smooth tongue sole Cynoglossus semilaevis. Fish and Shellfish Immunology. 32(4):609-15.

28. Yu Y, Zhong QQ, Li CM, Jiang LM, Sun YY, Wang XB, et al. Molecular cloning and characterization of Interleukin-1β in half-smooth tongue soleCynoglossus semilaevis. Veterinary Immunology and Immunopathology. In press.

29. 房新英, 张全启*, 齐洁, 包振民，2006，野生和养殖牙鲆(Paralichthys olivaceus)遗传差异的RAPD和ISSR研究。海洋与湖沼， 37（2）：138-142。

30. 李君竹, 张全启*, 齐洁，王兴莲，王志刚，2006，牙鲆（♀）×星鲽（♂）杂交子代的胚胎及仔鱼发育。中国水产科学， 13（5）:732-736。

31. 王旭波，张全启*，齐洁，王志刚，王兴莲, 2008. 牙鲆鳃细胞系染色体组型的变异分析。中国水产科学15（3）：483-487。

32. 孙业盈，张全启*，齐洁，王志刚，陈妍婕，李春梅，钟其旺，2008. 半滑舌鳎DMRT1基因的克隆与表达分析, 武汉大学学报(理学版) ，Vol. 54，No. 2 ：221～226。

33. 孙业盈，张全启*，齐洁，陈妍婕，李春梅，钟琪旺，王志刚，2008. 半滑舌鳎的一种细胞凋亡抑制因子的克隆、鉴定与分析。中国海洋大学学报，38（6）：927-931。

34. 徐建鹏，张全启，王志刚，齐洁，王旭波. 2009. ISSR 标记在牙鲆(Paralichthys olivaceus)与石鲽(Kareius bicoloratus)种间杂交一代的分离方式分析。海洋与湖沼，40（5）：1-5。

35. 徐建鹏，张全启*，王志刚，齐洁，王旭波. 2009。石鲽野生群体和养殖群体遗传多样性的ISSR分析。海洋学报31（4）：128-134。

36. 李朔，齐洁，王志刚，范玉顶，李春梅，刘志鹏，张全启*. 2009. 牙鲆Fibrinogen β基因的克隆及表达分析。中山大学学报，48(6)：89-94。

37. 庄岩，蓝勋，王志刚，王旭波，齐洁，张全启*. 2010. 牙鲆同质雌核发育二倍体的诱导及其早期生长研究。中国海洋大学学报，40(6): 96-102.

38. 杨俊杰，张全启*，刘保忠，刘坤. 2010. 鲽形目分类信息分析系统的建立与实现。中国海洋大学学报，40 (7): 59-65.

39. 严福升，王志刚，刘旭东，刘志鹏，张全启*. 2010. 3月龄牙鲆形态性状对体质量的通径分析。渔业科学进展，31（2）：45-50。

40. 范玉顶，陈妍婕，钟其旺，齐洁，张全启*. 2010. 利用DD-PCR分离鳗弧菌刺激相关的牙鲆差异cDNA。中国水产科学，17(3)：431-438。

41. 孙晓华，张全启*，王旭波，翟腾，齐洁，王志刚，王兴莲，王亚楠.2009. 半滑舌鳎雌鱼 Fosmid 基因组文库的构建及分析。中国海洋大学学报，40（8）：88-97.

42.姜黎明, 于海洋, 张全启*, 刘志鹏, 刘俊伟, 王旭波, 王志刚, 翟介明. 2011. 半滑舌鳎微卫星标记的开发及其在F1家系中分离方式分析。中国水产科学，18（6）：1384-1391。

43. 翟腾，王旭波，王晶，高金宁，翟介明，张全启*. 2011. 半滑舌鳎雌性特异fosmid克隆的筛选及FISH定位, 中国海洋大学学报，41 (11): 57-60。

张全启[中国海洋大学教授]