刘庄（苏州大学纳米科学技术学院教授）

人物经历

2008年至2009年在斯坦福大学化学系以及医学院从事博士后研究。

2009年6月加入苏州大学功能纳米与软物质(材料)实验室，被聘为教授，博士生导师。

主要成就

研究方向

纳米生物技术，癌症分子影像与检测，药物输送和癌症治疗。

代表论文

Chao Liang, Shuo Diao, Chao Wang, Hua Gong, Teng Liu, Guosong Hong, Xiaoze Shi, Hongjie Dai*, Zhuang Liu* “Tumor Metastasis Inhibition by Imaging-guided Photothermal Therapy with Single-walled Carbon Nanotubes”

Adv. Mater.

Chao Wang, Xiaoqi Sun, Liang Cheng, Shengnan Yin, Guangbao Yang, Yonggang Li, Zhuang Liu*, “Multifunctional theranostic red blood cells for magnetic field enhanced in vivo combination therapy of cancer”

Adv. Mater.

Liang Cheng, Wenjing Huang, Qiufang Gong, Changhai Liu, Zhuang Liu*, Yanguang Li* and Hongjie Dai “Ultra-Thin WS2 Nanoflakes as a Highly Efficient Electrocatalyst for Hydrogen Evolution Reaction”

Angew. Chem. Int. Ed.

Adv. Mater.

Liang Cheng, Jingjing Liu, Xing Gu, Hua Gong, Xiaoze Shi, Teng Liu, Chao Wang, Xiaoyong Wang, Gang Liu, Huaiyong Xing, Wenbo Bu, Baoquan Sun,Zhuang Liu*“PEGylated WSnanosheets as a multifunctional theranostic agent for in vivo dual-modal CT / photoacoustic imaging guided photothermal therapy”

Adv. Mater.

Zhiwei Li, Shengnan Yin, Liang Cheng, Kai Yang, Yonggang Li,Zhuang Liu*“Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer”

Adv. Funct. Mater.

Xuejiao Song, Hua Gong, Shengnan Yin, Liang Cheng, Chao Wang, Zhiwei Li, Yonggang Li, Xiaoyong Wang, Gang Liu,Zhuang Liu* "Ultra-small Iron Oxide Doped Polypyrrole Nanoparticles for in vivo Multimodal Imaging Guided Photothermal Therapy"

Adv. Funct. Mater.

Hua Gong, Rui Peng*,Zhuang Liu*“Carbon nanotubes for biomedical imaging: The recent advances”

Adv. Drug Delivery Rev.

Kai Yang, Liangzhu Feng, Hao Hong, Weibo Cai,Zhuang Liu*. “Preparation and functionalization of graphene nanocomposites for biomedical applications”

Nature Protocols

Chao Wang, Huan Xu, Chao Liang, Yumeng Liu, Zhiwei Li, Guangbao Yang, Liang Cheng, Yonggang Li,Zhuang Liu* “Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect”

ACS Nano,

Chao Wang, Liang Cheng, Xinxing Ma, Xiaojing Wang, Yumeng Liu, Zhaoyi Deng, Yonggang Li,Zhuang Liu* “Imaging-guided pH Sensitive Photodynamic Therapy using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light”

Adv. Funct. Mater.

Liang Cheng, Chao Wang, Xinxing Ma, Qinglong Wang, Yao Cheng, Han Wang, Yonggang Li,Zhuang Liu* “Multifunctional Upconversion Nanoparticles for Dual-modal Imaging Guided Stem Cell Therapy under Remote Magnetic Control”

Adv. Funct. Mater.

Kai Yang, Yingjie Li, Xiaofang Tan, Rui Peng*, Zhuang Liu* “Behavior and Toxicity of Graphene and Its Functionalized Derivatives in Biological Systems”

Small,

Kai Yang, Liangzhu Feng, Xiaoze Shi, Zhuang Liu* “Nano-graphene in biomedicine: theranostic applications”

Chem. Soc. Rev.

Liang Cheng, Chao Wang, Xinxing Ma, Qinglong Wang, Yao Cheng, Han Wang, Yonggang Li, Zhuang Liu* “Multifunctional Upconversion Nanoparticles for Dual-modal Imaging Guided Stem Cell Therapy under Remote Magnetic Control”

Adv. Funct. Mater

Kai Yang, Huan Xu, Liang Cheng, Chunyang Sun, Jun Wang, Zhuang Liu* “In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles”

Adv. Mater.

Liang Cheng, Kai Yang, Qian Chen, Zhuang Liu*, “Organic Stealth Nanoparticles for Highly Effective in Vivo Near-Infrared Photothermal Therapy of Cancer”

ACS Nano,

Xiaojing Wang, Chao Wang, Liang Cheng, Shuit-Tong Lee, Zhuang Liu* “Noble Metal Coated Single-walled Carbon Nanotubes for Applications in Surface Enhanced Raman Scattering Imaging and Photothermal Therapy”

J. Am. Chem. Soc.

Kai Yang, Lilei Hu, Xingxing Ma, Shuoqi Ye, Liang Cheng, Xiaoze Shi, Changhui Li, Yonggang Li, Zhuang Liu* “Multimodal imaging guided photothermal therapy using functionalized graphene nano-sheets anchored with magnetic nanoparticles”

Adv. Mater.

Chao Wang, Xinxing Ma, Shouqi Ye, Liang Guo, Changhui Li, Yonggang Li*, Zhuang Liu* “Protamine functionalized single-walled carbon nanotubes for stem cell labeling and in vivo Raman / magnetic resonance / photoacoustic triple-modal imaging”

Adv. Funct. Mater.

Bo Tian, Chao Wang, Shuai Zhang, Liangzhu Feng, Zhuang Liu* “Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide”

ACS Nano

Liang Cheng, Kai Yang, Yonggang Li, Jianhua Chen, Chao Wang, Mingwang Shao*, Shuit-Tong Lee, Zhuang Liu* “Facile preparation of multifunctional upconversion nanoprobes for multi-modal imaging and dual-targeted photothermal therapy”

Angew. Chem. Int. Ed

Kai Yang, Jianmei Wan, Shuai Zhang, Youjiu Zhang, Shuit-Tong Lee, Zhuang Liu* “In vivoPharmacokinetics, Long-Term Biodistribution, and Toxicology of PEGylated Graphene in Mice”

ACS Nano,

Chao Wang, Huiquan Tao, Liang Cheng, Zhuang Liu* “Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles”

Biomaterials,

Chao Wang, Liang Cheng, Zhuang Liu,* “Drug Delivery with Upconversion Nanoparticles for Multi-Functional Targeted Cancer Cell Imaging and Therapy”

Biomaterials,

Kai Yang, Shuai Zhang, Guoxin Zhang, Xiaoming Sun, Shuit-Tong Lee and Zhuang Liu,* “Graphene in Mice – Ultra-high in vivo Tumor Uptake and Highly Efficient Photothermal Therapy”

Nano Lett.

成果贡献

近年来一直在纳米医学与肿瘤纳米技术领域从事研究。

2005年以来发表学术论文100余篇，其中回国后独立发表通信作者论文70余篇，相当一部分成果发表于Chem. Soc. Rev., Nature Protocols, Angew. Chem. Int. Ed., JACS, Adv. Mater., Ad. Funct. Mater. Nano Lett., ACS Nano等国际权威刊物上。

全部论文总引用已超过11,000次，SCI H-index为48。获国家自然科学基金委优秀青年基金资助，江苏省杰出青年基金资助；作为课题负责人承担科技部973项目课题一项。

当前研究兴趣包括纳米材料的生物学效应与生物安全性研究；基于碳纳米材料的生物成像、药物输送和治疗治疗研究；稀土上转换发光纳米材料在生物传感、生物成像、以及癌症治疗上的应用；新型多功能复合纳米材料的开发及其在多模态癌症成像与治疗上的应用；基于有机高分子纳米材料的肿瘤光学治疗与联合治疗；以及基于纳米技术的干细胞研究和细胞疗法研究等。

应国际著名期刊Biomaterials主编、美国工程院院士Kam W. Leong教授邀请，刘庄教授出任Biomaterials杂志新一届副主编。刘庄教授是该期刊新一届编委中唯一一位来自中国大陆的副主编。

2021年8月，苏州大学功能纳米与软物质研究院教授刘庄、陈倩以及上海市肺科医院教授杨洋团队合作，开发了一种可吸入的含人血管紧张素转化酶2（hACE2）的纳米捕获剂。该药物能与人体内的宿主细胞竞争结合SARS-CoV-2，由此保护人体宿主细胞免受感染。该成果发表于美国《国家科学院院刊》。^[2]

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