张海林（河北医科大学医学与健康研究院院长）

人物经历

1987-1991年在河北医科大学药理教研室工作，任助教、讲师。

1996-1997年6月在英国伦敦大学做博士后，1997年6月-2001年10月在美国纽约大学西奈山医学中心做博士后，任职。

2002年受聘河北医科大学特聘教授，任药理教研室教授、博士生导师，药理教研室副主任，基础医学研究所药理研究室主任。

2003-2010任药学院副院长。

2007年起任药理教研室主任。

2010年起任基础医学院院长，基础医学研究所所长。

2012年12月，任河北医科大学副校长。^[2]

社会任职

中国神经科学学会常务理事，曾任中国药理学会、中国细胞生物学会理事；曾任河北省神经科学学会理事长，现任河北省药理学会理事长。《J Gen Physiol》、《Channels》编委；《神经药理学》、副主编；《中国药学》（英文版）、《中国药理学通报》编委。^[3]

主要成就

主持国家自然科学基金杰出青年科学基金项目、重点项目、面上项目、国际合作项目；国家973课题、国家863计划；美国国家卫生研究院（NIH）国际合作基金项目、科技部重大基础研究前期研究专项等。在国际高水平的学术杂志《Nature Cell Biology》《Neuron》《J Clin Invest》等发表SCI论文100多篇；研究成果获河北省自然科学一等奖，河北省科学技术一等奖。^[3]

药理学、神经科学，重点关注神经元兴奋性的离子通道机制及相关疾病、相关药物靶点研究。^[3]

1. Peng LY, Mirshahi T., Zhang HL., Hirsch J. and Logothetis DE (2003) Critical Determinants of the G Protein g Subunits in the Gbg Stimulation of G Protein-actiated Inwardly Rectifying Potassium (GIRK) Channel Actiity. J Biol Chem 278 (50), 50203–50211,
2. Chan KW, Zhang HL and Logothetis1 DL (2003) N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. The EMBO Journal, 22 (15) 3833-3843
3. Zhang H., Craciun LC, Mirshahi T, Rohács T, Lopes CMB, Jin T, and Logothetis DE. (2003) PIP2 Actiates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents. Neuron， 37（6）, 963-975
4. Lopes C M.B., Zhang H., Rohacs T, Jin T, Yang, J. and Logothetis D.E. (2002) Alterations in Consered Kir Channel-PIP2 Interactions Underlie Channelopathies. Neuron, 34, 933–944
5. Perez CA., Huang L., Rong M., Kozak JA., Zhang H., Max M. and Margolskee RF. (2002). A transient receptor potential channel expressed in taste receptor cells. Nature Neurosci. 5(11):1169-76.
6. Mirshahi T, Mittal , Zhang H, Linder ME, Logothetis DE. (2002) Distinct sites on G protein beta gamma subunits regulate different effector functions. J Biol Chem 277(39):36345-50.
7. He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE (2002) Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel actiity through interactions with the beta gamma subunits of G proteins. J Biol Chem 277:6088-96
8. Mirshahi T, Robillard L, Zhang H, Hebert TE, Logothetis DE (2002) Gbeta residues that do not interact with Galpha underlie agonist-independent actiity of K+ channels. J Biol Chem 277(9):7348-55
9. Rohac T., Lopes CMB., Mirshahi T., Jin T., Zhang H. & Logothetis DE. (2001). Assay pf phosphatidylinositol biphosphate regulation of potassium channels. In G protein pathways, part C: Effector mechanism. Methods in Enzymology, 345-357
10. Hughes TE, Zhang, HL, Logothetis DE, Berlot CH (2001). isualization of a functional Gaq-green fluorescent protein fusion in liing cells: Association with the plasma membrane is disrupted by mutational actiation and by elimination of palmitoylation sites, but not by actiation mediated by receptors or AlF4- . J Biol Chem, 276:4227-4235.
11. Kobrinsky E, Mirshahi T, Zhang H, Jin T, Logothetis DE (2000). Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization. Nature Cell Biology, 2:507-14.
12. Zhang,HL., He C., Yan XX, Mirshahi T and Logothetis DE. (1999) Actiation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nature Cell Biology, 1:183-188
13. He, C., Zhang, HL., Mirshahi, T. and Logothetis, D. (1999). Specific Gbg Interaction With a K+ Channel Distinguish Between Basal and Agonist-induced Currents. J. Bio. Chem, 274:12517-12524
14. Logothetis, E.D. & Zhang, HL. (1999) Gating of G protein-sensitie inwardly rectifying K+ channels through phosphatidylinositol 4,5-bisphosphate-dependent mechanism. J. Physiol. London, 520, 630
15. Zhang, H-L., T. B. Bolton, A. E. Piekarska & G. A. McPherson (1998). The electrophysiological effects of tetraphenylphosphonium and tetraphylboron on ascular somooth muscle. Eur. J. Pharmacol, 347(1), 119-23
16. Zhang, H-L & Bolton, T. B. (1996) ATP-sensitie potassium channels and their modulation by nucleotides and potassium channel openers in ascular smooth muscle cells. In: Smooth muscle excitation. Eds: Bolton T. B. & Tomita, T. Academic Press Limited. Chapter 12, pp 139-154
17. Zhang, H-L. & Bolton, T. B. (1996). Two types of ATP-sensitie potassium channels in rat portal ein smooth muscle cells. Br. J. Pharmacol. 118, 105-114
18. Zhang, H-L. & Bolton, T. B. (1995). Effects of UK-84149 on oltage-actiated calcium currents of single smooth muscle cells from guinea-pig and rabbit jejunum and rabbit coronary. Br. J. Pharmacol., 114, 1657-1665
19. Zhang, H-L. & Bolton, T. B. (1995). Actiation by Intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitie K-channel in smoothmuscle cells of rat mesenteric artery. Br. J. Pharmacol., 114, 662-672
20. Beech, D.J., Zhang, H., Nakao, K. & Bolton, T.B. (1993). Single channel and whole-cell K-currents eoked by lecromakalim in smooth muscle cells from the rabbit portal ein. Br. J. Pharmacol., 110, 583-590.
21. Beech, D.J., Zhang, H., Nakao, K. & Bolton, T.B. (1993). K channel actiation by nucleotide diphosphates and its inhibition by glibenclamide in ascular smooth muscle cells. Br. J. Pharmacol., 110, 573-582

A text book of fundamental medical pharmacology (英文)，编委，吉林科学技术出版社， 2004

1. 国家杰出青年科学基金 (30325038), 2004.1-2007.12
2. 美国国家卫生研究院NIH Fogarty 国际合作项目(1 R03 TW006020-01A1): Protein Kinase C-dependent inhibition of Kir channels, 2003.4-2006.4，
3. 科技部基础研究重大项目前期研究专项(2003CCA00300):细胞膜磷脂对离子通道功能的调节及其生理学意义, 2003.12-2005.12
4. 国家自然科学基金项目(30270361): 膜磷脂PIP2对M电流及KCNQ电流的调节作用. 2003.1-2005.12，
5. 河北省自然科学基金项目。磷脂酰肌醇二磷酸对M电流的调节及生理学意义（303464），2003.1-2005.12
6. 国家自然科学基金项目(30240001): 老年大鼠M电流的研究. 2002.1---2002.12,
7. 教育部科学技术研究重点项目(02016): pH调节内向整流钾离子通道功能的分子机制, 2002.1-2003.12

获得荣誉

国家杰出青年科学基金获得者，燕赵学者，中国侨联特聘专家，河北省省管专家，获中国侨联科技创新人才奖。^[3]获河北省十大科技杰出青年，享受国务院政府特殊津贴，河北省强势学科（药理学）带头人，省管优秀专家。^[2]