马庆军（中国科学院海洋研究所责任研究员）

基本信息

教育及工作经历

1993-1997 南开大学，微生物学学士

1997-2000 中国科学院生物物理研究所，分子生物学硕士，导师为董贻诚研究员和吴伸副研究员。

2000-2003哥廷根大学（University of Goettingen）结构化学系，自然科学博士（Dr.rer.nat.）,专业方向为结构生物学和结构化学，导师为世界著名晶体学专家，英国皇家科学院院士George M. Sheldrick教授。

2004-2007 欧洲分子生物学实验室汉堡分部(EMBL, Hamburg)，合作导师为Matthias Wilmanns 博士。

2008 马克斯普郎克协会结构分子生物学研究单元(Max-Planck Structural Molecular Biology Research Unit at Hamburg)，合作导师为Hans D. Bartunik博士。

2009-2010柏林自由大学 (Free University of Berlin)晶体学所，合作导师为世界著名结构生物学家Wolfram Saenger 教授。

2010-2014 吕贝克大学(University of Luebeck)生物化学所，研究组长。

2014-至今 中国科学院海洋研究所责任研究员。

承担项目情况

2014-2018引进海外人才启动资金，70万

2016-2019 国家自然科学基金面上项目，74.4万

发表文章情况

近5年来，在PNAS、Acta Crystallogr D、J Virol和J Biol Chem等国际权威期刊上发表论文20余篇，被他引逾500次。

22.Rocha-Pereira J, Nascimento MS, Ma Q, Hilgenfeld R, Neyts J, Jochmans D. The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon. Antimicrob Agents Chemother

21.Jian Lei, Jeroen R. Mesters, Christian Drosten, Stefan Anemüller, Qingjun Ma, Rolf Hilgenfeld. Crystal structure of the papain-like protease of MERS coronavirus reveals unusual,potentially druggable active-site features. Antiviral Res

20.Qingjun Ma, Yusuf Akhter, Matthias Wilmanns, and Matthias T. Ehebauer. Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis. Protein Science

19.Haydar Bulut, Qingjun Ma, Sebastien Moniot, Wolfram Saenger, Erwin Schneider, Ardeschir Vahedi-Faridi. Crystal structures of receptors involved in small molecule transport across membranes. Eur J Cell Biol

18.Yibei Xiao#, Qingjun Ma#, Tobias Restle, Weifeng Shang, Dmitri I. Svergun, Rajesh Ponnusamy, Georg Sczakiel, Rolf Hilgenfeld. Non-structural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer that Exhibits Primer-independent RNA Polymerase Activity. J Virol

17.Yijian Rao#, Qingjun Ma#, Ardeschir Vahedi-Faridi, Anna Sundborger, Arndt Pechstein, Dmytro Puchkov, Lin Luo,Oleg Shupliakov, Wolfram Saenger, Volker Haucke. Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation. P Natl Acad Sci USA

16.Yan-feng Zhou, Beiyan Nan , Jie Nan, Qingjun Ma, Santhosh Panjikar, Yu-he Liang, Yiping Wang, Xiao-dong Su. C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain. J Mol Bio

15.Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Corrondo MA, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider G, Schnell R, Stuart DI, Tarbouriech N, Unge T, Wilkinson AJ, Wilmanns M, Wilson KS, Zimhony O, Grimes JM. Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Acta Crystallogr D

14.Qingjun Ma, Xin Zhao, Ali Nasser Eddine, Arie Geerlof, Xinping Li, John E. Cronan, Stefan H. E. Kaufmann, Matthias Wilmanns. The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. P Natl Acad Sci USA

13.Madhumati Sevvana,Marianna Biadene, Qingjun Ma, Chaoshe Guo, Hans-Dieter Soeling, George M. Sheldrick, David M. Ferrari.Structural elucidation of the PDI-related chaperone Wind with the help of mutants. Acta Crystallogr D

12.Hongping Zhu, Rainer B. Oswald, Hongjun Fan, Herbert W. Roesky, Qingjun Ma, Zhi Yang , Hans-Georg Schmidt, Mathias Noltemeyer, Kerstin Starke, Narayan S. Hosmane. Aluminacyclopropene: Syntheses, characterization, and reactivity toward terminal alkynes. J Am Chem Soc

11.Kathrin Barnewitz, Chaoshe Guo, Madhumati Sevvana, Qingjun Ma, George M. Sheldrick, Hans-Dieter Soeling, David M. Ferrari. Mapping of a substrate binding site in the protein disulfide isomerase-related chaperone wind based on protein function and crystal structure. J Biol Chem

10.Jianfang Chai, Hongping Zhu, Qingjun Ma, Herbert W. Roesky, Hans-Georg Schmidt, Mathias Noltemeyer. Synthesis and structural characterization of three-coordinate Mn-II, Fe-II, and Zn-II complexes containing a bulky diamide ligand DippN(CH2)(3)NDipp (2-)(Dipp=2,6-iPr(2)C(6)H(3)). Eur J Inorg Chem

9. Hongping Zhu, Jianfang Chai, Qingjun Ma, Vojtech Jancik, Herbert W. Roesky, Hongjun Fan, Regine Herbst-Irmer. A seven-membered aluminum sulfur allenyl heterocycle arising from the conversion of an aluminacyclopropene with CS2. J Am Chem Soc

8.Qingjun Ma#, Chaoshe Guo#, Kathrin Barnewitz, George M. Sheldrick, Hans-Dieter Soeling, Isabel Uson,David M. Ferrari. Crystal structure and function analysis of Drosophila Wind – a PDI-related protein. J Biol Chem

7. Qing-jun Ma, Jian-hui Li, Hui-guang Li, Shen Wu, Yi-cheng Dong. Crystal structure of beta-luffin, a ribosome inactivating protein at 2.0Å resolution. Acta Crystallogr D

6. Judit E. Debreczeni, Gabor Bunkoczi, Qingjun Ma, Heiko Blaser, George M. Sheldrick. In-house measurement of the sulfur anomalous signal and its use for phasing. Acta Crystallogr D

5. Guangcai Bai , Qingjun Ma , Herbert W. Roesky, Denis Vidovic, Regine Herbst-Irmer. New synthetic route for organic polyoxometallic clusters: synthetic and structural investigations on the first dumb-bell shaped polyoxozirconium hydroxide with the [Zr-9(mu(5)-O)(2)(mu(3)-O)(4)(mu-O)(4)(mu-OH)(8)] core structure. Chem Commun

4. Yuqiang Ding , Qingjun Ma , Herbert W. Roesky, Isabel Uson , Mathias Noltemeyer, Hans-Georg Schmidt. Syntheses, structures and properties of [{HC(CMeNAr)(2)}Ge(E)X] (Ar=2,6-iPr(2)C(6)H(3); E = S, Se; X = F, Cl). Dalton T

3. Yuqiang Ding, Qingjun Ma, Herbert W. Roesky, Regine Herbst-Irmer, Isabel Uson, Mathias Noltemeyer, Hans-Georg Schmidt. Synthesis, structures, and reactivity of alkylgermanium(II) compounds containing a diketiminato ligand. Organometallics

2. Yuqiang Ding, Qingjun Ma, Isabel Uson, Herbert W. Roesky, Mathias Noltemeyer, Hans-Georg Schmidt. Synthesis and structures of [{HC(CMeNAr)(2)}Ge(S)X] (Ar=2,6-iPr(2)C(6)H(3), X = F, Cl, Me): Structurally characterized examples with a formal double bond between group 14 and 16 elements bearing a halide. J Am Chem Soc

1.Qing-jun Ma, Guang Yao, Shen Wu, Hui-guang Li, Jian-hui Li, Yi-cheng Dong. Crystallization and preliminary X-ray analysis of luffaculin, a ribosome-inactivating protein from sponge-gourd seeds. Acta Crystallogr D